Journal of Clinical Lipidology
Volume 2, Issue 4 , Pages 304-305 , August 2008

Point: Statins, plant sterol absorption, and increased coronary risk

  • Mark R. Goldstein, MD, FACP

      Affiliations

    • Fountain Medical Court, 9410 Fountain Medical Court, Suite A-200, Bonita Springs, FL 34135, USA
    • ,
  • Luca Mascitelli, MD

      Affiliations

    • Medical Service, Comando Brigata Alpina “Julia”, 8 Via S. Agostino, Udine, 33100, Italy
    • ,
  • Francesca Pezzetta, MD

      Affiliations

    • Cardiology Service, Ospedale di Tolmezzo, Tolmezzo, Italy

References 

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  2. Miettinen TA, Gylling H, Strandberg T, Sarna S Finnish 4S Investigators. Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian Simvastatin Survival Study. BMJ. 1998;316:1127–1130
  3. Berge KE, von Bergmann K, Lutjohann D, et al. Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. J Lipid Res. 2002;43:486–494
  4. Miettinen TA, Gylling H. Synthesis and absorbtion markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. Eur J Clin Invest. 2003;33:976–982
  5. Scandinavian Simvastatin Survival Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344:1383–1389
  6. Miettinen TA, Strandberg TE, Gylling H Finnish Investigators of the Scandinavian Simvastatin Survival Study Group. Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. Arterioscler Thromb Vasc Biol. 2000;20:1340–1346
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  13. Plat J, Brzezinka H, Lütjohann D, Mensink RP, von Bergmann K. Oxidized plant sterols in human serum and lipid infusions as measured by combined gas-liquid chromatography-mass spectrometry. J Lipid Res. 2001;42:2030–2038
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  15. Superko HR, King S. Is lowering low-density lipoprotein an effective strategy to reduce cardiac risk?. Circulation. 2008;117:560–568
  16. Azen SP, Mack WJ, Cashin-Hemphill L, et al. Progression of coronary artery disease predicts clinical coronary events: long-term follow-up from the Cholesterol Lowering Atherosclerosis Study. Circulation. 1996;93:34–41
  17. Brown G, Albers JJ, Fisher LD, et al. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med. 1990;323:1289–1298
  18. Patel MD, Thompson PD. Phytosterols and vascular disease. Atherosclerosis. 2006;186:12–19
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PII: S1933-2874(08)00266-3

doi: 10.1016/j.jacl.2008.06.005

Journal of Clinical Lipidology
Volume 2, Issue 4 , Pages 304-305 , August 2008

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