Journal of Clinical Lipidology
Volume 3, Issue 3 , Pages 159-166 , May 2009

Lipid-altering effects of different formulations of hydroxypropylmethylcellulose

  • Kevin C. Maki, PhD

      Affiliations

    • Provident Clinical Research, Bloomington, Indiana, USA
    • Provident Clinical Research, 489 Taft Avenue, Glen Ellyn, Illinois, USA
    • Corresponding Author InformationCorresponding author.
  • ,
  • Michael L. Carson, DO, MPH

      Affiliations

    • The Dow Chemical Company, Midland, Michigan, USA
  • ,
  • W.H. Kerr Anderson, PhD

      Affiliations

    • The Dow Chemical Company, Midland, Michigan, USA
  • ,
  • Jeffrey Geohas, MD

      Affiliations

    • Radiant Research, Chicago, Illinois, USA
  • ,
  • Matthew S. Reeves, DO

      Affiliations

    • Provident Clinical Research, Bloomington, Indiana, USA
  • ,
  • Mildred V. Farmer, MD

      Affiliations

    • Meridien Research, St. Petersburg, Florida, USA
  • ,
  • Maciej Turowski, PhD

      Affiliations

    • The Dow Chemical Company, Midland, Michigan, USA
  • ,
  • Marvin Miller, PhD

      Affiliations

    • The Dow Chemical Company, Midland, Michigan, USA
  • ,
  • Valerie N. Kaden

      Affiliations

    • Provident Clinical Research, 489 Taft Avenue, Glen Ellyn, Illinois, USA
  • ,
  • Mary R. Dicklin, PhD

      Affiliations

    • Provident Clinical Research, 489 Taft Avenue, Glen Ellyn, Illinois, USA
  • ,
  • Tia M. Rains, PhD

      Affiliations

    • Provident Clinical Research, 489 Taft Avenue, Glen Ellyn, Illinois, USA

Received 3 February 2009 ,Accepted 30 April 2009.

References 

  1. Burdock GA. Safety assessment of hydroxypropylmethylcellulose as a food ingredient. Food Chem Toxicol. 2007;45:2341–2351
  2. Dressman JB, Adair CH, Barnett JL, et al. High molecular-weight hydroxypropylmethylcellulose. A cholesterol-lowering agent. Arch Intern Med. 1993;153:1345–1353
  3. Swidan SZ, Reppas C, Barnett JL, et al. Ability of two comestible formulations of hydroxypropylmethylcellulose to lower serum cholesterol concentrations. Eur J Pharm Sci. 1996;4:239–245
  4. Maki KC, Davidson MH, Malik KC, Albrecht HH, O'Mullane J, Daggy BP. Cholesterol lowering with high-viscosity hydroxypropylmethylcellulose. Am J Cardiol. 1999;84:1198–1203
  5. Maki KC, Davidson MH, Torri S, et al. High-molecular weight hydroxypropylmethylcellulose taken with or between meals is hypocholesterolemic in adult men. J Nutr. 2000;130:1705–1710
  6. Maki KC, Carson ML, Miller MP, et al. Hydroxypropylmethylcellulose lowers cholesterol in statin-treated men and women with primary hypercholesterolemia. Eur J Clin Nutr., in press.
  7. Reppas C, Swidan SZ, Tobey SW, Turowski M, Dressman JB. Hydroxypropylmethylcellulose significantly lowers blood cholesterol in mildly hypercholesterolemic human subjects. Eur J Clin Nutr. 2009;63:71–77
  8. Reppas C, Meyer JH, Sirois PJ, Dressman JB. Effects of hydroxypropylmethylcellulose on gastrointestinal transit and luminal viscosity in dogs. Gastroenterology. 1991;100:1217–1223
  9. Reppas C, Greenwood DE, Dressman JB. Longitudinal versus radial effects of hydroxypropylmethylcellulose on gastrointestinal glucose absorption in dogs. Eur J Pharmacol Sci. 1999;8:211–219
  10. Carr P, Gallaher DD, Yang C, Hassel CA. Increased intestinal contents viscosity reduces cholesterol absorption efficiency in hamster fed hydroxypropylmethylcellulose. J Nutr. 1996;126:1463–1469
  11. Hong YJ, Turowski M, Lin JT, Yokoyama WH. Simultaneous characterization of bile acid, sterols, and determination of acylglycerides in feces from soluble cellulose-fed hamsters using HPLC with evaporative light-scattering detection and APCI–MS. J Agric Food Chem. 2007;55:9750–9757
  12. Braun WH, Ramsey JC, Gehring PJ. The lack of significant absorption of methylcellulose, viscosity 3300 CP, from the gastrointestinal tract following single and multiple oral doses to the rat. Food Cosmetic Toxicol. 1974;12:373–376
  13. Santos EM. Expert panel. Final report on the safety assessment of hydroxymethylcellulose, hydroxypropylcellulose, methylcellulose, hydroxypropylmethylcellulose, and cellulose gum. J Am Coll Toxicol. 1986;5:1–59
  14. Todd PA, Benfield P, Goa KL. Guar gum. A review of its pharmacological properties, and use as a dietary adjunct in hypercholesterolemia. Drugs. 1990;39:917–928
  15. Glore SR, Van Treeck D, Knehans AW, Guild M. Soluble fiber and serum lipids: a literature review. J Am Diet Assoc. 1994;94:425–436
  16. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation. 2002;106:3143–3421
  17. Peters JR, Quiter ES, Brekke ML, et al. The Eating Patterns Assessment Tool: a simple instrument for assessing dietary fat and cholesterol intake. J Am Diet Assoc. 1994;94:1008–1013
  18. Buemann B, Toubro S, Ruben A, Astrup A. Human tolerance to a single, high dose of D-tagatose. Reg Toxicol Pharmacol. 1999;29:866–870
  19. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  20. Maki KC, Carson ML, Miller MP, et al. High-viscosity hydroxypropylmethylcellulose blunts postprandial glucose and insulin responses. Diabetes Care. 2007;30:1039–1043
  21. Maki KC, Carson ML, Miller MP, et al. Hydroxypropylmethylcellulose and methylcellulose consumption reduce postprandial insulinemia in overweight and obese men and women. J Nutr. 2008;138:292–296
  22. Gallaher DD, Hassel CA, Lee K-J. Relationships between viscosity and hydroxypropyl methylcellulose and plasma cholesterol in hamsters. J Nutr. 1993;123:1732–1738
  23. Albert MA, Danielson E, Rifai N, Ridker PM for the PRINCE Investigators. Effects of statin therapy on C-reactive protein levels. The Pravastatin Inflammation/CRP Evaluation (PRINCE): a randomized trial and cohort study. JAMA. 2001;286:64–70
  24. Ajani UA, Ford ES, Mokdad AH. Dietary fiber and C-reactive protein: findings from National Health and Nutrition Examination Survey Data. J Nutr. 2004;134:1181–1185
  25. Nissen SE, Tuzcu EM, Schoenhagen P, et al. Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) Investigators Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med. 2005;352:29–38
  26. Basu A, Devaraj S, Jialal I. Dietary factors that promote or retard inflammation. Arterioscler Thromb Vasc Biol. 2006;26:995–1001
  27. King DE, Egan BM, Woolson RF, Mainous AG, Al-Solaiman Y, Jesro A. Effect of high-fiber diet vs. a fiber-supplemented diet on C-reactive protein level. Arch Intern Med. 2007;167:502–506
  28. Kinlay S. Low-density lipoprotein dependent and independent effects of cholesterol-lowering therapies on C-reactive protein: a meta-analysis. J Am Coll Cardiol. 2007;49:2003–2009
  29. Weickert MO, Pfeiffer AF. Metabolic effects of dietary fiber consumption and prevention of diabetes. J Nutr. 2008;138:439–442
  30. Pearson TA, Ballantyne CM, Veltri E, et al. Pooled analyses of effects on C-reactive protein and low density lipoprotein cholesterol in placebo-controlled trials of ezetimibe monotherapy or ezetimibe added to baseline statin therapy. Am J Cardiol. 2009;103:369–374
  31. Landin K, Holm G, Tengorn l, Smith U. Guar gum improves insulin sensitivity, blood lipids, blood pressure, and fibrinolysis in healthy men. Am J Clin Nutr. 1992;56:1061–1065
  32. Cicero AF, Derosa G, Manca M, Bove M, Borghy C, Gaddi AV. Different effect of psyllium and guar dietary supplementation on blood pressure and control in hypertensive overweight patients: a six-month, randomized clinical trial. Clin Exp Hypertens. 2007;29:383–394
  33. Hunninghake DB, Miller VT, LaRosa JC, et al. Hypocholesterolemic effects of a dietary fiber supplement. Am J Clin Nutr. 1994;59:1050–1054
  34. Anderson JW, Davidson MH, Blonde L, et al. Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia. Am J Clin Nutr. 2000;71:1433–1438
  35. Pasman WJ, Westerterp-Plantenga MA, Muls E, Vansant G, van Ree J, Saris WH. The effectiveness of long-term fibre supplementation on weight maintenance in weight-reduced women. Int J Obes Relat Metab Disord. 1997;21:548–555
  36. Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr. 1999;69:30–42

PII: S1933-2874(09)00200-1

doi: 10.1016/j.jacl.2009.04.053

Journal of Clinical Lipidology
Volume 3, Issue 3 , Pages 159-166 , May 2009