Journal of Clinical Lipidology
Volume 4, Issue 2 , Pages 99-104 , March 2010

Non-HDL-cholesterol/apolipoprotein B ratio: A useful distinguishing feature in the screening for type III hyperlipoproteinemia

  • Toshio Murase, MD, PhD

      Affiliations

    • Okinaka Memorial Institute for Medical Research, Toranomon 2-2-2, Minatoku, Tokyo 105-8470, Japan
    • Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan
    • Corresponding Author InformationCorresponding author.
    • ,
  • Minoru Okubo, MD, PhD

      Affiliations

    • Okinaka Memorial Institute for Medical Research, Toranomon 2-2-2, Minatoku, Tokyo 105-8470, Japan
    • Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan
    • ,
  • Ichiro Takeuchi, MD, PhD

      Affiliations

    • Tokyo Metropolitan Ohkubo Hospital, Toyko, Japan

Received 16 December 2009 ,Accepted 24 January 2010.

References 

  1. Mahley RW, Rall SC. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal lipoprotein metabolism. In:  Scriber CR,  Beaudet AL,  Aly WS,  Vallo O editor. The Metabolic and Molecular Basis of Inherited Disease. 8th ed. New York, NY: McGraw-Hill; 2001;p. 2835–2855
  2. Fredrickson DS, Morganroth J, Levy RI. Type III hyperlipoproteinemia: analysis of two contemporary deficiencies. Ann Intern Med. 1975;82:150–157
  3. Blom DJ, O'Neill , Marais AD. Screening for dysbetalipoproteinemia by plasma cholesterol and apolipoprotein B concentrations. Clin Chem. 2005;51:904–907
  4. Sniderman A, Tremblay A, Bergeron J, Gagne C, Couture P. Diagnosis of type III hyperlipoproteinemia from total cholesterol, triglyceride, and apolipoprotein B. J Clin Lipidol. 2007;1:256–263
  5. März W, Feussner G, Siekmeier R, et al. Apolipoprotein E to B ratio: a marker for type III hyperlipoproteinemia. Eur J Clin Chem Clin Biochem. 1993;31:743–747
  6. Toda Y, Kobayashi J, Higashikata T, et al. Detailed analysis of serum lipids and lipoproteins from Japanese type III hyperlipoproteinemia with apolipoprotein E2/2 phenotype. Clin Chim Acta. 2004;348:35–40
  7. Ishibashi S, Murase T, Yamada N, Tanaka K, Takaku F, Sato K. Hyperlipidaemia in patients with hypopituitarism. Acta Endocrinol. 1985;110:456–460
  8. Murase T, Yamada N, Uchimura H. Accumulation of intermediate density lipoprotein in the plasma of cholesterol-fed hypothyroid rats. Metabolism. 1983;32:146–150
  9. Okubo M, Aoyama Y, Harada K, et al. A novel apolipoprotein E2 variant, E2Toranomon (Q187E), identified in a type III hyperlipoproteinemia patient with coronary atherosclerosis. Atherosclerosis. 1988;140:187–190
  10. Arai T, Tsukada T, Murase T, Matsumoto K. Particle size analysis of high density lipoproteins in patients with genetic cholesteryl ester transfer protein deficiency. Clin Chim Acta. 2000;301:103–117
  11. Yamada N, Murase T, Akanuma Y, Itakura H, Kosaka K. Plasma apolipoprotein E levels in hypertriglyceridemia. Horm Metab Res. 1982;14:303–306
  12. Gotoda T, Yamada N, Kawamura M, et al. Heterogeneous mutations in the human lipoprotein lipase gene in patients with familial lipoprotein lipase deficiency. J Clin Invest. 1991;88:1856–1864
  13. Okubo M, Hasegawa Y, Aoyama Y, Murase T. A G+1 to C mutation in a donor splice site of intron 2 in the apolipoprotein (apo) C-II gene deficiency and apoE4 in a severely hypertriglyceridemic patient. Atherosclerosis. 1997;130:153–160
  14. Warnick GR, Nauck M, Refai N. Evaluation of methods for measurement of HDL-cholesterol: from ultracentrifugation to homogeneous assays. Clin Chem. 2001;47:1579–1596
  15. Ebara T, Murase T, Okubo M. Pancreatitis caused by hypertriglyceridemia in a patient compound heterozygous for Leu334Phe and —514C→T in the hepatic lipase gene. Pancreas. 2009;38:233–235
  16. Okubo M, Ishihara M, Iwasaki T, et al. A novel APOA5 splicing mutation IVS2+1g>a in a Japanese chylomicronemia patient. Atherosclerosis. 2009;207:24–25

PII: S1933-2874(10)00043-7

doi: 10.1016/j.jacl.2010.01.004

Journal of Clinical Lipidology
Volume 4, Issue 2 , Pages 99-104 , March 2010

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