Background
Metabolic syndrome is associated with increased cardiovascular disease (CVD) risk,
a risk that is significantly increased when accompanied by elevated low-density lipoprotein
cholesterol (LDL-C). Whereas lifestyle therapies are the initial intervention of choice
for both of these risk factors, it has not been clearly determined that this approach
is efficacious when they occur concomitantly.
Objective
To evaluate effects of supplementing a lifestyle program with a medical food and nutraceutical
in individuals with metabolic syndrome and elevated LDL-C.
Methods
We conducted a subgroup analysis of a 12-week, randomized trial in adults with metabolic
syndrome; data from those with LDL-C ≥ 160 mg/dL were analyzed. Control-arm subjects
were instructed to consume a modified Mediterranean-style, low-glycemic-load diet
(MED, n = 12). Treatment-arm subjects received a phytochemical-enhanced diet (PED,
n = 12) consisting of the same low-glycemic-load diet plus a medical food containing
soy protein and plant sterols and a nutraceutical containing hops rho iso-alpha acids and acacia proanthocyanidins. All subjects received identical aerobic
exercise counseling.
Results
At 12 weeks, mean weight loss did not differ between arms. However, the PED arm exhibited
greater improvement than the MED arm (P < .05) in total cholesterol, LDL-C, non−high-density lipoprotein cholesterol (non-HDL-C),
cholesterol/HDL-C, triglyceride/HDL-C, apolipoprotein (apo) B, apo B/apo A-1, homocysteine,
total LDL particle number, and large HDL particle number. All individuals in the PED
arm but only one third in the MED arm achieved LDL-C levels < 160 mg/dL.
Conclusion
Individuals at high CVD risk benefit from a soy/phytosterol containing medical food
and phytochemical supplemented lifestyle program.
Keywords
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Article info
Publication history
Published online: December 04, 2009
Accepted:
November 30,
2009
Received:
July 17,
2009
Identification
Copyright
© 2010 National Lipid Association. Published by Elsevier Inc. All rights reserved.
