Objectives
To determine the association of atherogenic index of plasma (AIP), the logarithm of
molar ratio of triglyceridemia to high-density lipoprotein cholesterol (TG/HDL-cholesterol)
with cardiometabolic disorders was investigated in a sample of the Turkish population.
Methods
A total of 2676 middle-aged adults were prospectively evaluated with a clinical examination
and laboratory tests during 7.8 years' follow-up.
Results
AIP was significantly associated in multiple linear regression analyses with greater
apolipoprotein B and lower low-density lipoprotein (LDL)-cholesterol levels, reflecting
the presence of smaller LDL particle size. Whereas in men insulin levels, obesity,
and nonHDL-cholesterol were major determinants, C-reactive protein (CRP) was the strongest
determinant of AIP among women, independent of body mass index. Top quartiles of AIP
predicted significantly age-adjusted incident coronary heart disease (CHD) in both
sexes, more strongly in women, in whom quartile 3 also was a predictor with a greater
than 2-fold relative risk. Associations remained significant after adjustment for
CRP and traditional risk factors. AIP significantly predicted diabetes and high blood
pressure in both sexes after adjustment for age and CRP. With regard to incident high
blood pressure, the risk ratio in men was attenuated when body mass index also was
adjusted.
Conclusions
High AIP, a surrogate of small LDL particle size, reflects obesity and hyperinsulinemia
in men and high CRP status in women. It predicts CHD independently, type 2 diabetes
mediated by obesity in men and in women, high blood pressure, metabolic syndrome,
and CHD potentially mediated by involvement in a proinflammatory status reflected
by CRP.
Keywords
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Article info
Publication history
Published online: February 15, 2010
Accepted:
February 8,
2010
Received:
December 28,
2009
Identification
Copyright
© 2010 National Lipid Association. Published by Elsevier Inc. All rights reserved.
