Highlights
- •Flaxseed can be effective in amelioration of some symptoms of metabolic syndrome.
- •Flaxseed oil consumption may decrease blood pressure and lipid peroxidation.
- •Flaxseed is one of the major vegetal sources of essential omega-3 fatty acids.
- •Sunflower seed oil is one of the most consumed sources of polyunsaturated fatty acids in the world.
Background
Metabolic syndrome (MetSyn) increases the risk of type II diabetes and morbidity and
mortality due to cardiovascular diseases. Flaxseed oil (FO), as a functional food,
is one of the major vegetal sources of essential omega-3 fatty acids.
Objective
This study aimed to compare the effects of consumption of FO and sunflower seed oil
(SO) on lipid peroxidation and other symptoms of MetSyn.
Methods
This randomized controlled interventional trial was conducted on 60 volunteers aged
30 to 60 years who were diagnosed with MetSyn in Shiraz, Iran. The participants who
fulfilled the inclusion criteria were randomly assigned to SO (n = 30, receiving 25 mL/d
SO) and FO (n = 30, receiving 25 ml/d FO) groups using block randomization. The diets
were identical for all the participants. Blood pressure (BP), serum lipid, fasting
blood sugar, and malondialdehyde were measured at baseline and at the end of week 7.
Result
The results showed no significant difference between the 2 groups regarding blood
lipid levels and fasting blood sugar at the end of the study. However, significant
reductions in total cholesterol, low-density lipoprotein cholesterol (5.6% in FO and
10.8% in SO), and triglyceride levels were seen within each group after treatment
with FO and SO (P < .05). Nonetheless, between-group changes were significant (<0.05) for systolic
BP (mean [±standard deviation {SD}] changes were −14.0 ± 22.41 in the FO group [P = .004] and 0.92 ± 8.70 in the SO group [P = .594]) and diastolic BP (mean [±SD] changes were −4.26 ± 7.44 in the FO group [P = .007] and 1.30 ± 6.91 in the SO group [P = .344]), but marginally significant (P = .053) for malondialdehyde level (mean [±SD] changes were −1.29 ± 1.48 in the FO
group [P < .001] and −0.52 ± 1.34 in the SO group [P = .52]). A significant decrease in weight was also found in both groups. However,
waist circumference decreased significantly only in the FO group at the end of the
study (P < .05).
Conclusion
Our results indicated that dietary FO could be effective in amelioration of some symptoms
of MetSyn and decrease BP and lipid peroxidation.
Keywords
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Article info
Publication history
Published online: November 20, 2017
Accepted:
November 7,
2017
Received:
December 28,
2016
Footnotes
Funding: This research was financially supported by the Research Vice-chancellor of Shiraz University of Medical Sciences, Shiraz, Iran (Grant No. 7420).
Identification
Copyright
© 2017 National Lipid Association. All rights reserved.
