Highlights
- •The ideal age for universal cholesterol screening has not been determined.
- •Thyroid hormone has a profound effect on lipid and lipoprotein metabolism.
- •Secondary causes of hypercholesterolemia should be excluded before therapy initiation.
Abstract
Routine and selective cholesterol screening of children is an effective tool to help
identify those with familial hypercholesterolemia. In children found to have elevated
levels of cholesterol, secondary causes should be excluded, including hypothyroidism.
Thyroid hormone has multiple effects on the regulation of lipid synthesis, absorption,
and metabolism. In this case report, we described a 2-year-old with a history of congenital
hypothyroidism who was found to have severe hypercholesterolemia. A detailed medical
history and appropriate screening tests are important in determining the underlying
cause of elevated low-density lipoprotein cholesterol to help inform clinical decision-making.
Keywords
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References
- Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report.Pediatrics. 2011; 128: S213-S256
- Child-parent screening for familial hypercholesterolaemia: screening strategy based on a meta-analysis.BMJ. 2007; 335: 5992
- Hyperlipidemia in patients with primary and secondary hypothyroidism.Mayo Clin Proc. 1993; 68: 860-866
- Hypothyroidism and dyslipidemia: modern concepts and approaches.Curr Cardiol Rep. 2004; 6: 451-456
- Dyslipidemia in patients with thyroid disorders.Hormones (Athens). 2002; 1: 218-223
- The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT study.Eur J Endocrinol. 2007; 156: 181-186
- Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function.J Clin Lip. 2017; 11: 1347-1353
- High-density lipoprotein cholesterol, hepatic lipase and lipoprotein lipase activities in thyroid dysfunction--effects of treatment.Q J Med. 1986; 59: 513-521
- Plasma lipoproteins and regulation of hepatic metabolism of fatty acids in altered thyroid states.Endocr Rev. 1985; 6: 590-607
- The activity of cholesteryl ester transfer protein is decreased in hypothyroidism: a possible contribution to alterations in high-density lipoproteins.Eur J Clin Invest. 1990; 20: 581-587
- Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies.Clin Endocrinol (Oxf). 1996; 44: 643-649
- Time-course of alterations of high density lipoproteins (HDL) during thyroxine administration to hypothyroid women.Eur J Clin Invest. 1987; 17: 313-316
- Changes in plasma low-density lipoprotein (LDL)- and high-density lipoprotein cholesterol in hypo- and hyperthyroid patients are related to changes in free thyroxine, not to polymorphisms in LDL receptor or cholesterol ester transfer protein genes.J Clin Endocrinol Metab. 2000; 85: 1857-1862
Article info
Publication history
Published online: March 27, 2019
Accepted:
March 20,
2019
Received:
November 15,
2018
Footnotes
Declarations of Interest: None.
Identification
Copyright
Published by Elsevier Inc. on behalf of National Lipid Association.
