- •The effects of DHA on LDL-C are controversial.
- •We compared changes over time in erythrocyte DHA and LDL-C levels in 9253 patients.
- •Increases in DHA levels were associated with increases in fish oil supplement use.
- •Changes in DHA levels were inversely associated with changes in LDL-C.
- •We found no evidence that the use of fish oil supplements raises LDL-C.
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Funding: The Cooper Institute, a 501(c)(3) nonprofit research institute, provided internal funding for this study.
Authors' contribution: Authors' contributions: NBR and WSH developed the research question and WSH wrote the article. DL performed statistical analysis and edited the article. CEB summarized the data and edited the article. NBR, MS, AP, BLW and LFD provided critical clinical input and edited the article.
Disclosures: WSH is the President of OmegaQuant Analytics, LLC, a laboratory that performed the omega-3 blood testing for this study. The other authors have no conflict of interest to declare in relation to the preparation and submission of this article.