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Disclosures and funding sources: Dr. Gianos reports support from an educational grant from AstraZeneca, speaker fee (moderator) from Kaneka and content expert/speaker fee from MedAxiom. Dr. Lau is supported by grants from the National Institutes of Health K23-HL159243, the American Heart Association #853922, and the Massachusetts General Hospital Corrigan Minehan Heart Center and Fireman Vascular Center SPARK Award. Dr. Lau discloses that she has received modest honoraria from Roche Diagnostics. Dr. El Khoudary reports support from the National Institute on Aging R01 AG058690. Dr. Guyton has received royalties from UpToDate.