- •OCT assessed neoatherosclerosis (NA) in statin-treated patients.
- •TG-rich lipoprotein (TRL) levels were significantly higher in the NA group.
- •Apolipoprotein (apo) C3, TRL-C, and apoB levels were risk factors for NA
- •LDL-C levels were similar in the NA and non-NA group.
Abbreviations:AA (indicates Arachidonic acid), ACS (Acute coronary syndrome), Apo (Apolipoprotein), AUC (Area under the curve), CAD (Coronary artery disease), CI (Confidence interval), DES (Drug eluting stent), eGFR (estimated glomerular filtration rate), EPA (Eicosapentaenoic acid), HbA1c (Glycated hemoglobin), HDL-C (High-density lipoprotein-cholesterol), Hs-CRP (High-sensitivity C-reactive protein), LDL-C (Low-density lipoprotein-C), MACE (Major adverse cardiovascular event), MDA-LDL (Malondialdehyde-modified low-density lipoprotein), NA (Neoatherosclerosis), Non-HDL-C (Non-high-density lipoprotein cholesterol), NT-proBNP (N-terminal pro-brain natriuretic peptide), OCT (Optical coherence tomography), OR (Odds ratio), PCI (Percutaneous coronary intervention), Sd-LDL-C (Small dense LDL-C), TG (Triglyceride), TRL-C (Triglyceride-rich lipoprotein-cholesterol), TRLs (Triglyceride-rich lipoproteins)
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Ethics approval and consent to participate: Written informed consent was obtained from all individuals, and the local ethics committee approved the protocol.
Consent for publication: Not applicable.
Availability of data and materials: The raw data will not be shared as the participants did not consent to this.
Author's contributions: RS, TS, and SK (Shinji Koba) contributed to the study design, manuscript preparation, data analysis, data interpretation, and critical revisions of the manuscript. TA, NM, YY, SS, HT (Hideaki Tanaka), and RM contributed to data acquisition and analysis. YO, KO, KA, KN, KS, HT (Hiroaki Tsujita), SK (Seita Kondo), and ST contributed to data acquisition. HM contributed to data analysis and interpretation. HS and TS (Toshiro Shinke) contributed to the data interpretation, critical revisions, and editing of the manuscript.
Declaration of competing interest: Shinji Koba and Toshiro Shinke received research funding from Denka Seiken Co., Ltd. and Abbott Medical. The other authors have no conflicts of interest to declare.
Funding: Shinji Koba and Toshiro Shinke received research funding from Denka Seiken Co., Ltd. and Abbott Medical. The funders had no role in this study.