- •Triglyceride-rich lipoproteins (TRLs) were independently associated with GlycA.
- •Medium and large TRLs were the main TRL subclasses related to GlycA.
- •Medium, large, and very large TRLs were associated with circulating leukocytes.
- •TRLs were more strongly related to neutrophils and lymphocytes than monocytes.
- •The total number of TRLs was not associated with C-reactive protein.
Abbreviations:ASCVD (Atherosclerotic cardiovascular disease), BMI (Body mass index), CAC (Coronary artery calcification), ELSA-Brasil (Brazilian Longitudinal Study of Adult Health), HDL (High-density lipoprotein), hs-CRP (High-sensitivity C-reactive protein), LDL (Low-density lipoprotein), NMR (Nuclear magnetic resonance), TRL (Triglyceride-rich lipoprotein)
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Conflict of interest: R.D.S. has received honoraria related to consulting, research, and/or speaker activities from Abbott, Ache, Amgen, Amryt, AstraZeneca, Biolab, Esperion, Getz Pharma, Kowa, Libbs, Novo Nordisk, Novartis, Merck, Pfizer, PTC Therapeutics, and Sanofi. M.S.B. has received honoraria related to consulting or speaker fees from Elucid, Cleerly, Novartis, Novo Nordisk, and Bayer. Other authors report no conflict of interest with this work.
Funding: This work was supported by the following Brazilian institutions: Ministry of Health, Department of Science and Technology (DECIT); Ministry of Science, Technology, and Innovation, Funding Authority for Studies and Projects (Portuguese: Financiadora de Estudos e Projetos [Finep]); and the National Council for Scientific and Technological Development (Portuguese: Conselho Nacional de Desenvolvimento Científico e Tecnológico [CNPq]), under the processes 01 06 0010.00 RS, 01 06 0212.00 BA, 01 060300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, and 01 06 0071.00 RJ.
RDS receives a research scholarship from the National Council for Scientific and Technological Development (Portuguese: Conselho Nacional de Desenvolvimento Científico e Tecnológico [CNPq]), Brazil, #303734/2018-3.