- •Direct LDL-C assay in children aged 2-6 years can be obtained in routine check-ups.
- •Family history for FH or premature CVD is not a reliable predictor in preschoolers.
- •On a population level positive family history is associated with higher LDL-C.
Abbreviations:ALDL (automated low density lipoprotein), BMI (body mass index), CVD (cardiovascular disease), FH (familial hypercholesterolemia), IQR (interquartile range), LDL-C (low-density lipoprotein cholesterol), Lp(a) (lipoprotein(a)), TC (total cholesterol)
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Conflict of Interest Disclosures (includes financial disclosures): The authors have no conflicts of interest relevant to this article to disclose.
Funding/Support: The Fr1dolin study has been supported by a grant of the Juvenile Diabetes Research Foundation (2-SRA-2016-243-Q-R), the Liona M. and Harry B. Helmsley Charitable Trust and Sanofi-Aventis Deutschland GmbH as well as from the non-profit associations ‘Freunde AUF DER BULT e.V.’ and ‘Kind und Diabetes e.V.
Role of Funder/Sponsor (if any): The Juvenile Diabetes Research Foundation, The Liona M. and Harry B. Helmsley Charitable Trust and Sanofi-Aventis Deutschland GmbH had no role in the design and conduct of the study. ‘Freunde AUF DER BULT e.V.’ and ‘Kind und Diabetes e.V.’ supported the publication of educational material.
Clinical Trial Registration (if any): ClinicalTrials.gov ID, NCT02750527, H-Fr1dolin-01, Pediatric Population Screening for Type 1 Diabetes and Familial Hypercholesterolemia in Lower Saxony, Germany (Fr1dolin), Data sharing after request to [email protected]
Contributors’ Statement Page
Prof Kordonouri conceptualized and designed the study, carried out the initial analyses, drafted the initial manuscript, and reviewed and revised the manuscript.
Dr Arens and Mrs Marquardt designed the data collection instruments, collected data, and reviewed and revised the manuscript.
Dr Christoph developed and supervised the LDL-C measurement method, collected data and reviewed and critically revised the manuscript.
Prof Lange designed the study, drafted the initial manuscript, supervised the statistical analyses and reviewed and critically revised the manuscript.
Prof Danne conceptualized and designed the study, supervised data collection, and critically reviewed the manuscript for important intellectual content and finally approved the version to be published.
All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.